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dc.contributor.authorW'Giorgis, Zemane
dc.date.accessioned2016-01-12T20:35:16Z
dc.date.available2016-01-12T20:35:16Z
dc.identifier.urihttp://hdl.handle.net/10464/7980
dc.description.abstractThis thesis describes work towards the total synthesis of a 7-aza analogue of the Amaryllidaceae alkaloid narciclasine, a potent anticancer compound which suffers from a poor solubility profile. A key strategy in the formation of the C-ring is the biotransformation of bromobenzene by E.coli JM109. The densely substituted heterocyclic A-ring is obtained by sequential directed ortho-metalation and the fragment union accomplished with an amide coupling and subsequent intramolecular Heck reaction.en_US
dc.language.isoengen_US
dc.publisherBrock Universityen_US
dc.subjectAza-Analoguesen_US
dc.subjectNarciclasineen_US
dc.subjectAmaryllidaceaeen_US
dc.subjectTotal Synthesisen_US
dc.titleApproach to the Synthesis of Aza-Analogues of Narciclasine through an Intramolecular Heck Reactionen_US
dc.typeElectronic Thesis or Dissertationen
dc.degree.nameM.Sc. Chemistryen_US
dc.degree.levelMastersen_US
dc.contributor.departmentDepartment of Chemistryen_US
dc.degree.disciplineFaculty of Mathematics and Scienceen_US
refterms.dateFOA2021-07-16T10:04:44Z


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