Show simple item record

dc.contributor.authorTrojanowski, Natalie S.
dc.date.accessioned2015-09-24T20:42:11Z
dc.date.available2015-09-24T20:42:11Z
dc.identifier.urihttp://hdl.handle.net/10464/7245
dc.description.abstractSarco(endo)plasmic reticulum calcium ATPase (SERCA) is a transmembrane protein whose function is regulated by its immediate lipid environment (annulus). The composition of the annulus is currently unknown or it’s susceptibility to a high saturated fat diet (HSFD). Furthermore it is uncertain if HSFD can protect SERCA from thermal stress. The purpose of the study was to determine SERCA annular lipid composition, resulting impact of a HSFD, and in turn, influence on SERCA activity with and without thermal stress. The major findings were annular lipids were shorter and more saturated compared to whole homogenate and HSFD had no effect on annular lipid composition or SERCA activity with and without thermal stress. Both average chain length and unsaturation index were positively correlated with SERCA activity with and without thermal stress. These findings suggest that annular lipid composition is different than whole homogenate and its composition appears to be related to SERCA function.en_US
dc.language.isoengen_US
dc.publisherBrock Universityen_US
dc.subjectSERCAen_US
dc.subjectLipid Annulusen_US
dc.subjectHigh Saturated Fat Dieten_US
dc.subjectProtein-Membrane Structure-Function Relationshipen_US
dc.subjectHeat Stressen_US
dc.titleThe Role of Membrane Lipid Composition on Sarco(endo)plasmic Reticulum Calcium ATPase Function in Rat Soleus Muscleen_US
dc.typeElectronic Thesis or Dissertationen_US
dc.degree.nameM.Sc. Applied Health Sciencesen_US
dc.degree.levelMastersen_US
dc.contributor.departmentApplied Health Sciences Programen_US
dc.degree.disciplineFaculty of Applied Health Sciencesen_US
refterms.dateFOA2021-07-16T11:40:05Z


Files in this item

Thumbnail
Name:
Brock_Trojanowski_Natalie_2015.pdf
Size:
1.356Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record