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dc.contributor.authorWarkentin, Matthew
dc.date.accessioned2015-09-23T20:12:38Z
dc.date.available2015-09-23T20:12:38Z
dc.identifier.urihttp://hdl.handle.net/10464/7242
dc.description.abstractSmall aggressive non-small cell lung carcinomas (SA-NSCLC) are characterized by spread to distant lymph nodes and metastases, even while the primary tumour remains small in size, as opposed to tumours that are relatively large before cancer progression. These small aggressive cancers present a challenge for clinical diagnosis and screening, carry grave prognosis, and may benefit from using a targeted approach to identify high-risk individuals. The objectives of this thesis were to identify factors associated with SA-NSCLC, and compare survivorship of stage IV SA-NSCLC to large stage IV NSCLC. Logistic and Cox regression analysis were performed using data from the National Lung Screening Trial (NLST). Model building was guided by knowledge of lung carcinogenesis and lung cancer prognostic factors. Previous diagnosis of emphysema and positive family history of lung cancer in females were associated with increased risk of SA-NSCLC among adenocarcinomas. Despite overall poor prognosis, SA-NSCLC have a better prognosis compared to large stage IV NSCLC.en_US
dc.language.isoengen_US
dc.publisherBrock Universityen_US
dc.subjectlung canceren_US
dc.subjectepidemiologyen_US
dc.subjectaggressiveen_US
dc.subjectnon-small cellen_US
dc.subjectsurvivorshipen_US
dc.titleFactors Associated with Small Aggressive Non-Small Cell Lung Carcinomasen_US
dc.typeElectronic Thesis or Dissertationen_US
dc.degree.nameM.Sc. Applied Health Sciencesen_US
dc.degree.levelMastersen_US
dc.contributor.departmentApplied Health Sciences Programen_US
dc.degree.disciplineFaculty of Applied Health Sciencesen_US
refterms.dateFOA2021-07-16T11:39:04Z


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