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dc.contributor.authorEverett, Karl
dc.date.accessioned2015-08-27T13:31:10Z
dc.date.available2015-08-27T13:31:10Z
dc.identifier.urihttp://hdl.handle.net/10464/7072
dc.description.abstractThe study aim was to investigate the relationship between factors related to personal cancer history and lung cancer risk as well as assess their predictive utility. Characteristics of interest included the number, anatomical site(s), and age of onset of previous cancer(s). Data from the Prostate, Lung, Colorectal and Ovarian Screening (PLCO) Cancer Screening Trial (N = 154,901) and National Lung Screening Trial (N = 53,452) were analysed. Logistic regression models were used to assess the relationships between each variable of interest and 6-year lung cancer risk. Predictive utility was assessed through changes in area-under-the-curve (AUC) after substitution into the PLCOall2014 lung cancer risk prediction model. Previous lung, uterine and oral cancers were strongly and significantly associated with elevated 6-year lung cancer risk after controlling for confounders. None of these refined measures of personal cancer history offered more predictive utility than the simple (yes/no) measure already included in the PLCOall2014 model.en_US
dc.language.isoengen_US
dc.publisherBrock Universityen_US
dc.subjectlung canceren_US
dc.subjectsubsequent primary canceren_US
dc.subjectcancer historyen_US
dc.subjectrisk predictionen_US
dc.subjectepidemiologyen_US
dc.titleAssociations Between Personal Cancer History and Lung Cancer Risken_US
dc.typeElectronic Thesis or Dissertationen_US
dc.degree.nameM.Sc. Applied Health Sciencesen_US
dc.degree.levelMastersen_US
dc.contributor.departmentApplied Health Sciences Programen_US
dc.degree.disciplineFaculty of Applied Health Sciencesen_US
refterms.dateFOA2021-07-31T01:36:57Z


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