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dc.contributor.authorTurnbull, Patrick Carson
dc.date.accessioned2014-10-29T19:53:19Z
dc.date.issued2014-10-29
dc.identifier.urihttp://hdl.handle.net/10464/5787
dc.description.abstractThe first and rate-limiting step of lipolysis is the removal of the first fatty acid from a triglyceride molecule; it is catalyzed by adipose triglyceride lipase (ATGL). ATGL is co-activated by comparative gene identification-58 (CGI-58) and inhibited by the G(0)/G(1) switch gene-2 protein (G0S2). G0S2 has also recently been identified as a positive regulator of oxidative phosphorylation within the mitochondria. Previous research has demonstrated in cell culture, a dose dependent mechanism for inhibition by G0S2 on ATGL. However our data is not consistent with this hypothesis. There was no change in G0S2 protein content during an acute lipolytic inducing set of contractions in both whole muscle, and isolated mitochondria yet both ATGL and G0S2 increase following endurance training, in spite of the fact that there should be increased reliance on intramuscular lipolysis. Therefore, inhibition of ATGL by G0S2 appears to be regulated through more complicated intracellular or post-translation regulation.en_US
dc.language.isoengen_US
dc.publisherBrock Universityen_US
dc.subjectLipolysis, Intramuscular triglycerides, skeletal muscle metabolism, fat metabolismen_US
dc.titleSkeletal muscle protein content of lipolytic inhibitor G(0)/G(1) switch gene-2 protein: the effect of endurance trainingen_US
dc.typeElectronic Thesis or Dissertationen_US
dc.degree.nameM.Sc. Applied Health Sciencesen_US
dc.degree.levelMastersen_US
dc.contributor.departmentApplied Health Sciences Programen_US
dc.degree.disciplineFaculty of Applied Health Sciencesen_US
dc.embargo.lift2015-08-25T19:53:19Z
dc.embargo.terms10 Monthsen_US
refterms.dateFOA2021-07-31T01:44:39Z


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