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dc.contributor.authorNaimi, Madina
dc.date.accessioned2014-09-10T14:35:25Z
dc.date.available2014-10-31T09:00:03Z
dc.date.issued2014-09-10
dc.identifier.urihttp://hdl.handle.net/10464/5694
dc.description.abstractSkeletal muscle (SKM) is the most important tissue in maintaining glucose homeostasis and impairments in this tissue leads to insulin resistance (IR). Activation of 5’ AMP-activated kinase (AMPK) is viewed as a targeted approach to counteract IR. Rosemary extract (RE) has been reported to decrease blood glucose levels but its effects on SKM are not known. We hypothesized that RE acts directly on SKM to increase glucose uptake (GU). We found an increase in GU (184±5.07% of control, p<0.001) in L6 myotubes by RE to levels similar to insulin and metformin. Carnosic acid (CA) and rosmarinic acid (RA), major polyphenols found in RE, increased GU. RE, CA, and RA significantly increased AMPK phosphorylation and their effects on GU was reduced by an AMPK inhibitor. Our study is the first to show a direct effect of RE, CA and RA on SKM GU by a mechanism that involves AMPK activation.en_US
dc.language.isoengen_US
dc.publisherBrock Universityen_US
dc.subjectRosemary extracten_US
dc.subjectskeletal muscleen_US
dc.subjectglucose uptakeen_US
dc.subjectAMPKen_US
dc.subjectglucose transportersen_US
dc.titleInvestigating the Biological Effects of Rosemary (Rosmarinus officinalis L.) Extract on Skeletal Muscle Glucose Uptakeen_US
dc.typeElectronic Thesis or Dissertationen_US
dc.degree.nameM.Sc. Applied Health Sciencesen_US
dc.degree.levelMastersen_US
dc.contributor.departmentApplied Health Sciences Programen_US
dc.degree.disciplineFaculty of Applied Health Sciencesen_US
dc.embargo.terms1 Monthen_US
refterms.dateFOA2021-08-04T02:56:09Z


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