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dc.contributor.authorAdams, David
dc.date.accessioned2014-07-18T20:10:59Z
dc.date.available2014-07-18T20:10:59Z
dc.date.issued2014-07-18
dc.identifier.urihttp://hdl.handle.net/10464/5510
dc.description.abstractThe present studies describe our recent progress in target oriented synthesis of complex organic molecules from aromatic precursors. The latest synthetic approaches toward vinca alkaloids are described and include the construction of model substrates for the investigation into Diels-Alder, radical cascade, and tandem Michael addition reactions as possible routes to the family of alkaloids. Also described are the chemoenzymatic syntheses of the natural product (-)-idesolide and unnatural polyhydroxylated pyrrolidines generated from the biotransformation of benzoic acid with Ralstonia eutropha B9.en_US
dc.language.isoengen_US
dc.publisherBrock Universityen_US
dc.subjectalkaloid synthesis chemoenzymatic organic chemistryen_US
dc.titleThe Use of Ipso-dihydrodiols Enzymatically Derived from Benzoic Acid in Enantioselective Synthesis. Appoaches to Total Synthesis of Vinca Alkaloidsen_US
dc.typeElectronic Thesis or Dissertationen_US
dc.degree.namePh.D. Chemistryen_US
dc.degree.levelDoctoralen_US
dc.contributor.departmentDepartment of Chemistryen_US
dc.degree.disciplineFaculty of Mathematics and Scienceen_US
dc.embargo.termsNoneen_US
refterms.dateFOA2021-07-31T01:55:15Z


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