TGA2 dual activity: N-terminus regulation of reversible DNA binding influenced by NPRI and CK2
dc.contributor.author | Bigby, Christina | |
dc.date.accessioned | 2013-02-22T19:16:06Z | |
dc.date.available | 2013-02-22T19:16:06Z | |
dc.date.issued | 2013-02-22 | |
dc.identifier.uri | http://hdl.handle.net/10464/4199 | |
dc.description.abstract | TGA2 is a dual-function Systemic Acquired Resistance (SAR) transcription factor involved in the activation and repression of pathogenesis-related (PR) genes. Recent studies have shown that TGA2 is able to switch from a basal repressor to activator, likely, through regulatory control from its N-terminus. The N-terminus has also been shown to affect DNA binding of the TGA2 bZIP domain when phosphorylated by Casein Kinase II (CK2). The mechanisms involved for directing a switch from basal repressor to activator, and the role of kinase activity, have not previously been looked at in detail. This study provides evidence for the involvement of a CK2-like kinase in the switch of TGA2 activity from repressor to activator, by regulating the DNA-binding activity of TGA2 by phosphorylating residues in the N terminus of the protein. | en_US |
dc.publisher | Brock University | en_US |
dc.subject | Systemic Acquired Resistance | en_US |
dc.title | TGA2 dual activity: N-terminus regulation of reversible DNA binding influenced by NPRI and CK2 | en_US |
dc.type | Electronic Thesis or Dissertation | en |
dc.degree.name | M.Sc. Biotechnology | en_US |
dc.degree.level | Masters | en_US |
dc.contributor.department | Centre for Biotechnology | en_US |
dc.degree.discipline | Faculty of Mathematics and Science | en_US |
dc.embargo.terms | None | en_US |