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Enantiodivergent chemoenzymatic synthesis of Balanol and approaches to the synthesis of (+)-Codine
(Brock University, 2010-10-25)
The present thesis reviews the development of a formal enantiodivergent
synthesis of the (+)- and (-)-isomers of balanol. This approach commences from a
cis-dihydrodiol derived from the enzymatic ...
Stereoselective synthesis of 5-substituted pyrrolo[1,2-c]imidazol-3-ones. Access to aldosterone synthase inhibitors and chiral precatalysts
(Brock University, 2010-10-26)
Compounds containing the pyrrolidine moiety are key substructures of
compounds with biological activity and organocatalysts. In particular, annulated
chiral pyrrolidines with alpha stereogenic ...
Two enantiodivergent syntheses of balanol and the chemoenzymatic synthesis of oseltamivir
(Brock University, 2010-10-25)
The present thesis outlines our latest findings on the reactivity of the Burgess
reagent with oxiranes. Structural, mechanistic, and computational studies are
presented. Included is the development of a ...