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dc.contributor.authorStegne, Marina
dc.date.accessioned2011-09-09T15:30:42Z
dc.date.available2011-09-09T15:30:42Z
dc.date.issued2011-09-09
dc.identifier.urihttp://hdl.handle.net/10464/3394
dc.description.abstractThis thesis describes an ancillary project to the Early Diagnosis of Mesothelioma and Lung Cancer in Prior Asbestos Workers study and was conducted to determine the effects of asbestos exposure, pulmonary function and cigarette smoking in the prediction of pulmonary fibrosis. 613 workers who were occupationally exposed to asbestos for an average of 25.9 (SD=14.69) years were sampled from Sarnia, Ontario. A structured questionnaire was administered during a face-to-face interview along with a low-dose computed tomography (LDCT) of the thorax. Of them, 65 workers (10.7%, 95%CI 8.12—12.24) had LDCT-detected pulmonary fibrosis. The model predicting fibrosis included the variables age, smoking (dichotomized), post FVC % splines and post- FEV1% splines. This model had a receiver operator characteristic area under the curve of 0.738. The calibration of the model was evaluated with R statistical program and the bootstrap optimism-corrected calibration slope was 0.692. Thus, our model demonstrated moderate predictive performance.en_US
dc.language.isoengen_US
dc.publisherBrock Universityen_US
dc.subjectasbestosisen_US
dc.subjectasbestosen_US
dc.subjectpredictionen_US
dc.subjectprevalenceen_US
dc.titleTHE PREVALENCE AND PREDICTION OF PULMONARY FIBROSIS IN ANen_US
dc.typeElectronic Thesis or Dissertationen_US
dc.degree.nameM.Sc. Applied Health Sciencesen_US
dc.degree.levelMastersen_US
dc.contributor.departmentApplied Health Sciences Programen_US
dc.degree.disciplineFaculty of Applied Health Sciencesen_US
refterms.dateFOA2021-08-07T02:48:06Z


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