• Login
    View Item 
    •   Repository Home
    • Brock Theses
    • Masters Theses
    • M.Sc. Computer Science
    • View Item
    •   Repository Home
    • Brock Theses
    • Masters Theses
    • M.Sc. Computer Science
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Evolutionary synthesis of stochastic gene network models using feature-based search spaces

    Thumbnail
    View/Open
    Brock_Imada_Janine_2009.pdf (2.948Mb)
    readme.rtf (897bytes)
    Data Files (168.7Mb)
    Data Files (154.7Mb)
    Data Files (348.8Mb)
    Date
    2009-01-28
    Author
    Imada, Janine.
    Metadata
    Show full item record
    Abstract
    A feature-based fitness function is applied in a genetic programming system to synthesize stochastic gene regulatory network models whose behaviour is defined by a time course of protein expression levels. Typically, when targeting time series data, the fitness function is based on a sum-of-errors involving the values of the fluctuating signal. While this approach is successful in many instances, its performance can deteriorate in the presence of noise. This thesis explores a fitness measure determined from a set of statistical features characterizing the time series' sequence of values, rather than the actual values themselves. Through a series of experiments involving symbolic regression with added noise and gene regulatory network models based on the stochastic 'if-calculus, it is shown to successfully target oscillating and non-oscillating signals. This practical and versatile fitness function offers an alternate approach, worthy of consideration for use in algorithms that evaluate noisy or stochastic behaviour.
    URI
    http://hdl.handle.net/10464/2853
    Collections
    • M.Sc. Computer Science

    Brock University | Copyright © 2006-2015 
    Contact Us | Send Feedback
     

     

    Browse

    All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    View Usage Statistics

    Brock University | Copyright © 2006-2015 
    Contact Us | Send Feedback