Browsing Brock University Publications & Manuscripts by Author "cd01a8ae-0d88-4883-9390-656eaf474913"

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Calmodulin-Binding Proteins in Muscle: A Minireview on Nuclear Receptor Interacting Protein, Neurogranin, and Growth-Associated Protein 43

Moradi, Fereshteh; Copeland, Emily N; Baranowski, Ryan W; Scholey, Aiden E; Stuart, Jeffrey A; Fajardo, Val A (MDPI, 2020)

Calmodulin (CaM) is an important Ca2+-sensing protein with numerous downstream targets that are either CaM-dependant or CaM-regulated. In muscle, CaM-dependent proteins, which are critical regulators of dynamic Ca2+ handling ...
A Low-Therapeutic Dose of Lithium Inhibits GSK3 and Enhances Myoblast Fusion in C2C12 Cells

Kurgan, Nigel; Whitley, Kennedy C; Maddalena, Lucas A; Moradi, Fereshteh; Stoikos, Joshua; Hamstra, Sophie I; Rubie, Elizabeth A; Kumar, Megha; Roy, Brian D; Woodgett, James R; Stuart, Jeffrey A; Fajardo, Val A (MDPI, 2019)

Glycogen synthase kinase 3 (GSK3) slows myogenic differentiation and myoblast fusion partly by inhibiting the Wnt/β-catenin signaling pathway. Lithium, a common medication for bipolar disorder, inhibits GSK3 via Mg+ ...
SERCA2a tyrosine nitration coincides with impairments in maximal SERCA activity in left ventricles from tafazzin deficient mice

Braun, Jessica L.; Hamstra, Sophie I.; Messner, Holt N.; Fajardo, Val A. (The Physiological Society, 2019-08)

The sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) is imperative for normal cardiac function regulating both muscle relaxation and contractility. SERCA2a is the predominant isoform in cardiac muscles and is inhibited by ...