Browsing M.Sc. Chemistry by Subject "Neopinone"
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Chemoenzymatic Synthesis of ent-NeopinoneThe present thesis describes the chemoenzymatic synthesis of ent-neopinone. The total synthesis of neopinone was accomplished in 14 steps from B-bromoethylbenzene. The synthesis began with a microbial oxidation of bromobenzene by Escherichia coli JM109(pDTG601) and features a Heck reaction, aldol condensation and a 1,6-conjugate addition.