• Chemoenzymatic Synthesis of ent-Neopinone

      Piercy, T. Graeme; Department of Chemistry (2013-04-11)
      The present thesis describes the chemoenzymatic synthesis of ent-neopinone. The total synthesis of neopinone was accomplished in 14 steps from B-bromoethylbenzene. The synthesis began with a microbial oxidation of bromobenzene by Escherichia coli JM109(pDTG601) and features a Heck reaction, aldol condensation and a 1,6-conjugate addition.