Browsing Ph.D. Chemistry by Author "Lapinskaite, Ringaile"

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    • Synthesis and Derivatization of Amaryllidaceae Constituents – Narciclasine and Pancratistatin
      Lapinskaite, Ringaile; Department of Chemistry
      This thesis describes the synthesis and derivatization of narciclasine and pancratistatin. A detailed description is given to the total formal synthesis of pancratistatin through a reductive transposition approach and the total and semi-syntheses of 2-epi-narciclasine and its discovery as a new natural product. The last part of this work focuses on the search for a divergent approach to access C-1 narciclasine and C-1-pancratistatin derivatives from natural narciclasine. Experimental and spectral data are provided for the new compounds.