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dc.contributor.authorThomson, Jared
dc.date.accessioned2022-11-02T19:41:46Z
dc.date.available2022-11-02T19:41:46Z
dc.identifier.urihttp://hdl.handle.net/10464/16880
dc.description.abstractThe generation of new structural derivatives of narciclasine, an Amaryllidaceae alkaloid, has been explored. The strategy applied to the semi-synthesis of these derivatives involves a key enolization step that produces an enol at the C1 position. This material was converted into a triflate to functionalize the C1 position through cross-coupling. Initial triflation attempts resulted in functionalization at C6 instead, and the C6 triflate was successfully coupled with different functionalities. All the novel C6 derivatives were fully deprotected and subjected to evaluation of their biological activity. Experimental and spectral data are provided for all new compoundsen_US
dc.language.isoengen_US
dc.publisherBrock Universityen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectOrganic Chemistryen_US
dc.subjectNarciclasineen_US
dc.subjectAmaryllidaceaeen_US
dc.titleSemi-synthesis of Unnatural Narciclasine Derivativesen_US
dc.typeElectronic Thesis or Dissertationen_US
dc.degree.nameM.Sc. Chemistryen_US
dc.degree.levelMastersen_US
dc.contributor.departmentDepartment of Chemistryen_US
dc.degree.disciplineFaculty of Mathematics and Scienceen_US
refterms.dateFOA2022-11-02T19:41:47Z


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Except where otherwise noted, this item's license is described as Attribution 4.0 International