Role of the Myokine Irisin on Bone Homeostasis: Review of the Current Evidence
Journal title
International Journal of Molecular SciencesPublication Volume
22Publication Issue
17Publication Begin page
9136
Metadata
Show full item recordAbstract
Bone is a highly dynamic tissue that is constantly adapting to micro-changes to facilitate movement. When the balance between bone building and resorption shifts more towards bone resorption, the result is reduced bone density and mineralization, as seen in osteoporosis or osteopenia. Current treatment strategies aimed to improve bone homeostasis and turnover are lacking in efficacy, resulting in the search for new preventative and nutraceutical treatment options. The myokine irisin, since its discovery in 2012, has been shown to play an important role in many tissues including muscle, adipose, and bone. Evidence indicate that irisin is associated with increased bone formation and decreased bone resorption, leading to reduced risk of osteoporosis in post-menopausal women. In addition, low serum irisin levels have been found in individuals with osteoporosis and osteopenia. Irisin targets key signaling proteins, promoting osteoblastogenesis and reducing osteoclastogenesis. The present review summarizes the existing evidence regarding the effects of irisin on bone homeostasis.ae974a485f413a2113503eed53cd6c53
10.3390/ijms22179136
Scopus Count
Collections
The following license files are associated with this item:
- Creative Commons