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dc.contributor.authorSadeghi, Sara.en_US
dc.date.accessioned2009-06-04T14:09:28Z
dc.date.available2009-06-04T14:09:28Z
dc.date.issued2007-06-04T14:09:28Z
dc.identifier.urihttp://hdl.handle.net/10464/1554
dc.description.abstractFormulations of a general bactericidal agent, chlorhexidine, mixed with a phospholipid at different concentrations are investigated using ^H NMR spectroscopy on a chain-deuterated lipid analog. Lipid-chlorhexidine formulation is known to release the drug into an aqueous medium slowly, maintaining a comparable concentration of the drug for up to four times longer than a direct aqueous solution. The NMR data does not support the proposed liposomal entrapment of chlorhexidine in lipid compartments. Complex thermal history of the lipid-chlorhexidine preparations is investigated in detail. In preparation for a counterpart measurement, using ^H NMR of deuterated chlorhexidine mixed with protonated lipid, the synthesis of a deuterated analog of chlorhexidine is performed.en_US
dc.language.isoengen_US
dc.publisherBrock Universityen_US
dc.subjectChlorhexidine.en_US
dc.subjectLipids.en_US
dc.titleOrder and membrane organization in chlorhexidine-lipid mixtures /en_US
dc.typeElectronic Thesis or Dissertationen_US
dc.degree.nameM.Sc. Physicsen_US
dc.degree.levelMastersen_US
dc.contributor.departmentDepartment of Physicsen_US
dc.degree.disciplineFaculty of Mathematics and Scienceen_US


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