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dc.contributor.authorCarlson, Brenden Matthew
dc.date.accessioned2021-04-20T12:32:04Z
dc.date.available2021-04-20T12:32:04Z
dc.identifier.urihttp://hdl.handle.net/10464/15055
dc.description.abstractHydroamidation of carbon–carbon double bonds is an attractive strategy for installing nitrogen functionality into molecular scaffolds and, with it, increasing molecular complexity. To date, metal-based approaches have dominated this area of chemical synthesis despite the drawbacks of air and moisture sensitivity, limited functional group tolerance, toxicity, and/or high cost often associated with using metals. Herein is enclosed an operationally simple, metal-free, one-pot, regioselective, multicomponent synthetic procedure for the hydroamidation of carbon–carbon double bonds. This method features mild reaction conditions and utilizes isocyanides and vinyl ethers for the rapid and modular synthesis of α-oxygenated amide scaffolds. Additional effort was put towards synthesizing reactive natural products as substrates to the developed methodology, and drafting a probable catalytic cycle for the main and side reactions present within this multicomponent procedure.en_US
dc.language.isoengen_US
dc.publisherBrock Universityen_US
dc.subjectisocyanideen_US
dc.subjectenol etheren_US
dc.subjectglycal sugaren_US
dc.subjecthydroamidationen_US
dc.subjectPasserini-likeen_US
dc.titleHydroamidation of Vinyl Ethers by Acid-Catalyzed Multicomponent Isocyanide Additionen_US
dc.typeElectronic Thesis or Dissertationen_US
dc.degree.nameM.Sc. Chemistryen_US
dc.degree.levelMastersen_US
dc.contributor.departmentDepartment of Chemistryen_US
dc.degree.disciplineFaculty of Mathematics and Scienceen_US


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