• Login
    View Item 
    •   Home
    • Brock University Publications & Manuscripts
    • Open Access Publishing Fund
    • 2020 Open Access Fund Recipients
    • View Item
    •   Home
    • Brock University Publications & Manuscripts
    • Open Access Publishing Fund
    • 2020 Open Access Fund Recipients
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of BrockUCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjectsProfilesView

    My Account

    LoginRegister

    Statistics

    Display statistics

    Anticancer Properties of Carnosol: A Summary of In Vitro and In Vivo Evidence

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    antioxidants-09-00961-v2.pdf
    Size:
    882.3Kb
    Format:
    PDF
    Description:
    Main article
    Download
    Author
    O’Neill, Eric J.
    Den Hartogh, Danja J.
    Azizi, Karim
    Tsiani, Evangeli
    Keyword
    Carnosol
    Apoptosis
    Cancer
    Proliferation
    Survival
    In vitro
    
    Metadata
    Show full item record
    URI
    http://hdl.handle.net/10464/14962
    Abstract
    Cancer is characterized by unrestricted cell proliferation, inhibition of apoptosis, enhanced invasion and migration, and deregulation of signalling cascades. These properties lead to uncontrolled growth, enhanced survival, and the formation of tumours. Carnosol, a naturally occurring phyto-polyphenol (diterpene) found in rosemary, has been studied for its extensive antioxidant, anti-inflammatory, and anticancer effects. In cancer cells, carnosol has been demonstrated to inhibit cell proliferation and survival, reduce migration and invasion, and significantly enhance apoptosis. These anticancer effects of carnosol are mediated by the inhibition of several signalling molecules including extracellular signal-regulated kinase (ERK), p38, c-Jun N-terminal kinase (JNK), Akt, mechanistic target of rapamycin (mTOR) and cyclooxygenase-2 (COX-2). Additionally, carnosol prevents the nuclear translocation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and promotes apoptosis, as indicated by increased levels of cleaved caspase-3, -8, -9, increased levels of the pro-apoptotic marker Bcl-2-associated X (BAX), and reduced levels of the anti-apoptotic marker B-cell lymphoma 2 (Bcl-2). The current review summarizes the existing in vitro and in vivo evidence examining the anticancer effects of carnosol across various tissues.
    ae974a485f413a2113503eed53cd6c53
    10.3390/antiox9100961
    Scopus Count
    Collections
    2020 Open Access Fund Recipients

    entitlement

     
    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.