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dc.contributor.authorJaglanian, Alina
dc.date.accessioned2019-11-19T15:51:08Z
dc.date.available2019-11-19T15:51:08Z
dc.identifier.urihttp://hdl.handle.net/10464/14566
dc.description.abstractBreast and prostate cancer are the most frequently diagnosed cancers in women and men respetively, in North America. Triple-negative breast cancer (TNBC) cells do not express estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2 (HER-2). TNBC accounts for 15% of all breast cancer cases, is aggressive in nature, and is characterized by resistance to chemo and radiotherapy thus, finding new approaches to inhibit it are urgently needed. Similarly, prostate cancer is typically characterized by the expression of androgen receptor (AR) and prostate-specific antigen (PSA). Prostate cancer that is AR positive can be treated with hormonal therapy. In contrast, AR negative prostate cancer is more aggressive and does not respond to hormone therapy, thus new approaches, including identifying specific signaling molecules that are overactivated and could be targeted, are required to effectively treat this subtype of prostate cancer. Rosemary extract (RE) has been shown to have anti-cancer properties in vitro and in vivo. However, limited evidence exists regarding its effect on triple-negative breast cancer and AR negative prostate cancer. In this study, we examined the effects of RE on triple-negative breast cancer cell (MDA-MB-231) and androgen insensitive prostate cancer cell (PC-3) proliferation, survival/apoptosis, and migration. In addition, we investigated the effect of RE treatment on key signaling molecules involved in cancer cell proliferation and survival.en_US
dc.language.isoengen_US
dc.publisherBrock Universityen_US
dc.subjectCanceren_US
dc.subjectRosemaryen_US
dc.subjectPolyphenolsen_US
dc.subjectProliferationen_US
dc.subjectSurvivalen_US
dc.subjectCell Cultureen_US
dc.titleInvestigation of the anti-cancer effects of rosemary (Rosmarinus Officinalis L.) extract in human breast and prostate cancer cellsen_US
dc.typeElectronic Thesis or Dissertationen_US
dc.degree.nameM.Sc. Applied Health Sciencesen_US
dc.degree.levelMastersen_US
dc.contributor.departmentApplied Health Sciences Programen_US
dc.degree.disciplineFaculty of Applied Health Sciencesen_US
refterms.dateFOA2021-08-15T01:56:35Z


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