• Login
    View Item 
    •   Home
    • Brock Theses
    • Masters Theses
    • M.A. Applied Disability Studies
    • View Item
    •   Home
    • Brock Theses
    • Masters Theses
    • M.A. Applied Disability Studies
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of BrockUCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjectsProfilesView

    My Account

    LoginRegister

    Statistics

    Display statistics

    Tamoxifen or Estradiol Limited to the Induction Phase of Nicotine Sensitization Enhances the Expression of Locomotor Sensitization in Ovariectomized and in Intact Female Rats

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Brock_Baumbach_Jennet_2019.pdf
    Size:
    1.332Mb
    Format:
    PDF
    Download
    Author
    Baumbach, Jennet
    Keyword
    Estradiol
    Nicotine
    Locomotor Sensitization
    Tamoxifen
    Female
    
    Metadata
    Show full item record
    URI
    http://hdl.handle.net/10464/14553
    Abstract
    In both humans and rodents, females are more vulnerable to addiction than males, which has been linked to higher concentrations of the hormone estradiol in females. In rats, nicotine injections produce greater sensitization (neurological changes responsible for drug cravings) in females than in males, which could contribute to sex differences in susceptibility to addiction. The purpose of these experiments was to investigate the effects of estradiol during three nicotine injections (two consecutive days and a third injection nine days later). Results from these experiments indicate that depletion of estradiol via ovariectomy attenuates nicotine sensitization in females, which can be rescued by estradiol injection limited to the induction phase of sensitization. Administration of tamoxifen (antagonist at nuclear estradiol receptors, agonist of the membrane-bound estradiol receptor GPER1) did not alter sensitization in gonadally intact rats, and was sufficient to restore expression of sensitization in ovariectomized females (similar to estradiol). Findings from these experiments indicate that the enhancing effects of estradiol on nicotine sensitization occur during the induction phase, and may be mediated by membrane bound estrogen receptors (e.g., GPER1).
    Collections
    M.A. Applied Disability Studies

    entitlement

     
    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.