• SERCA2a tyrosine nitration coincides with impairments in maximal SERCA activity in left ventricles from tafazzin deficient mice 

  Braun, Jessica L.; Hamstra, Sophie I.; Messner, Holt N.; Fajardo, Val A. (The Physiological Society, 2019-08)

  The sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) is imperative for normal cardiac function regulating both muscle relaxation and contractility. SERCA2a is the predominant isoform in cardiac muscles and is inhibited by ...

• Changes to the Human Serum Proteome in Response to High Intensity Interval Exercise: A Sequential Top-Down Proteomic Analysis 

  Kurgan, Nigel; Noaman, Nour; Pergande, Melissa R.; Cologna, Stephanie M.; Coorssen, Jens R.; Klentrou, Panagiota (Frontiers, 2019-04-02)

  Exercise has been shown to improve health status and prevent chronic diseases. In contrast, overtraining can lead to maladaptation and detrimental health outcomes. These outcomes appear to be mediated in part by released ...

• Antidiabetic Properties of Naringenin: A Citrus Fruit Polyphenol 

  Den Hartogh, Danja J.; Tsiani, Evangelia (MDPI, 2019-03-12)

  Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by insulin resistance and hyperglycemia and is associated with personal health and global economic burdens. Current strategies/approaches of insulin ...

• Acute exercise and brain BACE1 protein content: a time course study 

  Yang, Alex J.; Hayward, Grant C.; MacPherson, Rebecca E. K. (American Physiological Society, 2019-04-08)

  Obesity and insulin resistance are risk factors in the development of neurodegenerative disorders. Previous work suggests that one acute bout of exercise may have beneficial neuro-protective effects in obese mice. The rate ...

• Evaluation of neuropathological effects of a high-fat high-sucrose diet in middle-aged male C57BL6/J mice 

  Baranowski, Bradley J; Bott, Kirsten N.; MacPherson, Rebecca E. K. (American Physiological Society, 2018-05-15)

  Metabolic dysfunction related to diet-induced obesity has recently been linked to the pathogenesis of sporadic Alzheimer’s disease (AD). However, the underlying mechanisms linking obesity and AD remain unclear. The purpose ...

• Identification and Characterization of microRNAs during Retinoic Acid-Induced Regeneration of a Molluscan Central Nervous System 

  Walker, Sarah E; Spencer, Gaynor E.; Necakov, Aleksander; Carlone, Robert L. (MDPI, 2018-09-13)

  Retinoic acid (RA) is the biologically active metabolite of vitamin A and has become a well-established factor that induces neurite outgrowth and regeneration in both vertebrates and invertebrates. However, the underlying ...

• Meaningful connections in dementia end of life care in long term care homes 

  McCleary, Lynn; Thompson, Genevieve N; Venturato, Lorraine; Wickson-Griffiths, Abigail; Hunter, Paulette; Sussman, Tamara; Kaasalainen, Sharon (BMC, 2018)

  Background: Most persons with dementia die in long term care (LTC) homes, where palliative approaches are appropriate. However, palliative approaches have not been widely implemented and there is limited understanding of ...

View more