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dc.contributor.authorFixon-Owoo, Solomon N. K.en_US
dc.date.accessioned2009-05-21T13:54:22Z
dc.date.available2009-05-21T13:54:22Z
dc.date.issued2000-05-21T13:54:22Z
dc.identifier.urihttp://hdl.handle.net/10464/1345
dc.description.abstractThe monoconjugates of phenolic acids (i.e. coumaric acid) with polyamines such as spermidine and spermine are strikingly similar to some toxins from spiders and predatory wasps. Many plants contain phenolic acid polyamine conjugates and there is some reliable information supporting their roles as plant defense chemicals. Eleven monoacylated compounds of diamines, triamines, tetraamines and oxa-polyamine amines were prepared in three to seven steps: 22, 23, 24, 25, 26, 27, 28, 29, 30, 31 and 32. The synthesis proceeds through stepwise construction of the polyamine backbone (as in 62 and 72), followed by protection and deprotection steps of the amino functions. Desymmetrization of readily available and prepared symmetrical polyamines is a key step in the synthesis. The protecting groups employed were tert-butoxycarbonyl (BOC) and trifluoroacetyl (TFA) group which were removed under different conditions: acid and base respectively. Deprotection and refunctionalization of the polyamine reagent demonstrated the versatility of these systems for N-acylation.en_US
dc.language.isoengen_US
dc.publisherBrock Universityen_US
dc.subjectPolyaminesen_US
dc.subjectAmidesen_US
dc.subjectInsecticides.en_US
dc.titleSynthesis of 4-hydroxycinnamic amides of di-, tri-, and tetraamines : potential insect toxins /en_US
dc.typeElectronic Thesis or Dissertationen_US
dc.degree.nameM.Sc. Chemistryen_US
dc.degree.levelMastersen_US
dc.contributor.departmentDepartment of Chemistryen_US
dc.degree.disciplineFaculty of Mathematics and Scienceen_US
refterms.dateFOA2021-08-07T02:17:03Z


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