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dc.contributor.authorNelson, Katlynne
dc.date.accessioned2018-03-07T21:24:55Z
dc.date.available2018-03-07T21:24:55Z
dc.identifier.urihttp://hdl.handle.net/10464/13328
dc.description.abstractThe effect of a single-bout of plyometric exercise on markers of bone turnover and Wnt signalling-related osteokines was studied in 20 younger, pre-menopausal women (23.142.33 years) and 20 older, post-menopausal women (57.904.35 years of age). Blood samples were obtained at rest (i.e., pre-exercise) and 5 min, 1h, and 24h post- exercise and were analyzed for C-terminal crosslinking telopeptides of type I collagen (CTX), osteoprotegerin (OPG), sclerostin and dickkopf-1 (DKK-1), and estradiol. Resting levels of CTX, OPG, and sclerostin were significantly higher while DKK-1 and estradiol were significantly lower in older compared to younger women. CTX was higher at 5 min post-exercise compared to pre-exercise in younger women (326.027.0 vs. 292.029.0 pg/mL; p=0.049); however, no response was seen in older women. Sclerostin significantly decreased from 5 min (319.934.6 pg/mL) to 1h post-exercise (245.329.5 pg/mL) but increased between 1h and 24h post-exercise (368.333.9 pg/mL) only in younger women. DKK-1 decreased in both groups. In younger women, the decrease was continuous from 5 min (2560.20120.65 pg/mL) to 24h post-exercise (2176.60115.29 pg/mL, p=0.006). In post-menopausal women, the decrease was between pre-exercise (1949.69177.95 pg/mL) and 1h post-exercise (1549.82187.11 pg/mL, p=0.001) but returning to near pre-exercise levels 24h post-exercise. In the older women, OPG also decreased from pre-exercise (535.8  36.8 pg/mL) to 5 min post-exercise (475.1 39.0 pg/mL; p=0.048) and remained lower than baseline for up to 24h post-exercise (505.032.4 pg/mL; p=0.046). No changes were seen in the younger women. These results suggest that in women, one session of plyometric exercise is sufficient to induce significant changes in bone turnover and Wnt signalling related osteokines, however, the timing of the response varies significantly between age groups.en_US
dc.language.isoengen_US
dc.publisherBrock Universityen_US
dc.subjectBoneen_US
dc.subjectPlyometricen_US
dc.subjectExerciseen_US
dc.subjectSclerostinen_US
dc.titleThe effect of plyometric exercise on bone turnover markers and osteokines in younger and older womenen_US
dc.typeElectronic Thesis or Dissertationen
dc.degree.nameM.Sc. Applied Health Sciencesen_US
dc.degree.levelMastersen_US
dc.contributor.departmentApplied Health Sciences Programen_US
dc.degree.disciplineFaculty of Applied Health Sciencesen_US
refterms.dateFOA2021-08-05T01:59:19Z


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