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dc.contributor.authorHildering, Andrew
dc.date.accessioned2017-01-09T16:54:39Z
dc.date.available2017-01-09T16:54:39Z
dc.identifier.urihttp://hdl.handle.net/10464/10864
dc.description.abstractThis thesis is focused on the investigation of synthesizing a fluorescent analogue of vitamin E, α-tocopentaenol (αT5). α-Tocopentaenol contains five conjugated double bonds across the phytyl tail, resulting in its fluorescence characteristics. Different methodologies of preparation were attempted to synthesize an all trans-configuration in the five-conjugated double bonds. Unfortunately, across the C3’ bond on the tail, geometric isomers were obtained. However, TBSO-αT5 was produced in what appeared to be ≈ 2:1 E:Z mixture across the C3’ bond (having the four other olefins with trans-configurations). α-Tocopentaenol showed a strong absorbance in ethanol with a maximum λab= 338 nm. This compound is stable as an oil, stored at -78˚C and protected from light for over a month with minimal degradation. Because αT5 resembles the naturally occurring form of the vitamin E, this analogue will enhance our ability to study the biological activity of vitamin E and will create an easy method of monitoring its presence in solution and cells.en_US
dc.language.isoengen_US
dc.publisherBrock Universityen_US
dc.subjectVitamin Een_US
dc.subjectTocopherolen_US
dc.subjectFluorescenceen_US
dc.titleThe Synthesis of α-Tocopentaenol (αT5), a Fluorescent Analogue of α-Tocopherolen_US
dc.typeElectronic Thesis or Dissertationen_US
dc.degree.nameM.Sc. Chemistryen_US
dc.degree.levelMastersen_US
dc.contributor.departmentDepartment of Chemistryen_US
dc.degree.disciplineFaculty of Mathematics and Scienceen_US
refterms.dateFOA2021-08-04T03:40:03Z


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