A Bicyclic L-Proline Derived Chiral Auxiliary for Asymmetric Synthesis
dc.contributor.author | Emberson, Kassandra | |
dc.date.accessioned | 2016-03-11T16:47:15Z | |
dc.date.available | 2016-03-11T16:47:15Z | |
dc.identifier.uri | http://hdl.handle.net/10464/8687 | |
dc.description.abstract | This thesis describes the use of an L−proline-derived chiral auxiliary for diastereoselective lithiation and ligand synthesis. Such compounds have been utilized in the Metallinos research group previously for the synthesis of N−substituted planar chiral ferrocenes. The first project describes the use of this chiral auxiliary as a directing group for N−benzyl substitution, providing products in up to 10:1 diastereomeric ratio (dr). These derivatives may serve as chiral ylidene precursors to serve as ligands in transition metal catalysis. In addition, an N−substituted planar chiral ferrocene ylidene ligand derived from the same chiral auxiliary was used to prepare rhodium complexes that were explored as potential catalysts for asymmetric hydroformylation. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Brock University | en_US |
dc.subject | ylidene, chiral, chiral auxiliary, asymmetric, lithiation | en_US |
dc.title | A Bicyclic L-Proline Derived Chiral Auxiliary for Asymmetric Synthesis | en_US |
dc.type | Electronic Thesis or Dissertation | en |
dc.degree.name | M.Sc. Chemistry | en_US |
dc.degree.level | Masters | en_US |
dc.contributor.department | Department of Chemistry | en_US |
dc.degree.discipline | Faculty of Mathematics and Science | en_US |
refterms.dateFOA | 2015-12-23T00:00:00Z |