Show simple item record

dc.contributor.authorZibamanzarmofrad, Maral
dc.date.accessioned2015-10-06T15:27:36Z
dc.date.available2015-10-06T15:27:36Z
dc.identifier.urihttp://hdl.handle.net/10464/7279
dc.description.abstractDuchenne muscular dystrophy is a X-linked muscle disease, which leads to alterations in membrane phospholipid fatty acid (FA) composition and skeletal muscle damage. Increased membrane saturated FA in muscular dystrophy may suggest its association with increased susceptibility (as being the cause or consequence) to muscle damage. It was hypothesised that increased saturation is positively correlated to increased muscle damage. Correlations were hypothesized to be greater in extensor digitorum longus (EDL) at 20 weeks compared to soleus (SOL) at 10 weeks in dystrophin deficient (mdx) mice. Increased saturation was correlated to damage in EDL at both 10 and 20 weeks, with stronger correlations at 10 weeks. The results suggest that membrane PL FA composition may be associated with damage through two possible means. Increased saturation may be a cause or consequence of membrane damage. Association of membrane composition with eccentric induced damage has underscored the importance of saturated PL FA compositions in damage to dystrophic myofibres.en_US
dc.language.isoengen_US
dc.publisherBrock Universityen_US
dc.subjectmdxen_US
dc.subjectfatty aciden_US
dc.subjectmuscular dystrophyen_US
dc.subjectmembrane damageen_US
dc.titleThe Role of Membrane Lipid Composition on Skeletal Muscle Damage in the Rodent Model of Duchenne Muscular Dystrophyen_US
dc.typeElectronic Thesis or Dissertationen_US
dc.degree.nameM.Sc. Applied Health Sciencesen_US
dc.degree.levelMastersen_US
dc.contributor.departmentApplied Health Sciences Programen_US
dc.degree.disciplineFaculty of Applied Health Sciencesen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record