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dc.contributor.authorZelisko, Paul M
dc.contributor.authorFrampton, Mark B.
dc.contributor.authorJones, Tim RB
dc.date.accessioned2015-08-05T19:32:59Z
dc.date.available2015-08-05T19:32:59Z
dc.date.issued2015-11-28
dc.identifier.citationRSC Advances 2015, 5, 1999-2008en_US
dc.identifier.isbn1905688555
dc.identifier.issn2046-2069
dc.identifier.otherDOI: 10.1039/C4RA14828B
dc.identifier.urihttp://hdl.handle.net/10464/6987
dc.description.abstractImmobilized lipase B from Candida antarctica (Novozym® 435, N435) was utilized as part of a chemoenzymatic strategy for the synthesis of branched polyesters based on a cyclotetrasiloxane core in the absence of solvent. Nuclear magnetic resonance spectroscopy and matrix-assisted laser desorption ionization time-of-flight mass spectrometry were utilized to monitor the reactions between tetraester cyclotetrasiloxanes and aliphatic diols. The enzyme-mediated esterification reactions can achieve 65– 80% consumption of starting materials in 24–48 h. Longer reaction times, 72–96 h, resulted in the formation of cross-linked gel-like networks. Gel permeation chromatography of the polymers indicated that the masses were Mw ¼ 11 400, 13 100, and 19 400 g mol 1 for the substrate pairs of C7D4 ester/ octane-1,8-diol, C10D4 ester/pentane-1,5-diol and C10D4 ester/octane-1,8-diol respectively, after 48 h. Extending the polymerization for an additional 24 h with the C10D4 ester/octane-1,8-diol pair gave Mw ¼ 86 800 g mol 1. To the best of our knowledge this represents the first report using lipase catalysis to produce branched polymers that are built from a cyclotetrasiloxane core.en_US
dc.description.sponsorshipNatural Sciences and Engineering Research Council (NSERC) of Canada Brock University Advanced Biomanufacturing Centreen_US
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistryen_US
dc.subjectsilicon chemistryen_US
dc.subjectcyclosiloxaneen_US
dc.subjectsiloxaneen_US
dc.subjectlipaseen_US
dc.subjectbiotechnologyen_US
dc.subjectbiocatalysisen_US
dc.subjecttransesterificationen_US
dc.titleCyclotetrasiloxane Frameworks for the Chemoenzymatic Synthesis of Oligoestersen_US
dc.typeArticleen_US
refterms.dateFOA2021-07-30T01:36:59Z


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