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dc.contributor.authorLiang, Ping
dc.date.accessioned2015-03-04T19:04:59Z
dc.date.available2015-03-04T19:04:59Z
dc.date.issued2014-02
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/10464/6137
dc.description.abstractcell of origin and triggering events for leukaemia are mostly unknown. Here we show that the bone marrow contains a progenitor that expresses renin throughout development and possesses a B-lymphocyte pedigree. This cell requires RBP-J to differentiate. Deletion of RBP-J in these renin-expressing progenitors enriches the precursor B-cell gene programme and constrains lymphocyte differentiation, facilitated by H3K4me3 activating marks in genes that control the pre-B stage. Mutant cells undergo neoplastic transformation, and mice develop a highly penetrant B-cell leukaemia with multi-organ infiltration and early death. These reninexpressing cells appear uniquely vulnerable as other conditional models of RBP-J deletion do not result in leukaemia. The discovery of these unique renin progenitors in the bone marrow and the model of leukaemia described herein may enhance our understanding of normal and neoplastic haematopoiesis.en_US
dc.description.sponsorshipUniversity of Virginia Children’s Medical Center internal grant support (BCB and RAG), the Karen Jargowsky Research Fund (BCB), and the National Institutes of Health (grants RO1 DK 091330 to MLSSL and Merit Award R37 HL 066242 to RAG).en_US
dc.language.isoenen_US
dc.subjectMYELOID-LEUKEMIAen_US
dc.subjectDEVELOPING KIDNEYen_US
dc.subjectGENE-EXPRESSIONen_US
dc.subjectANGIOTENSIN SYSTEMen_US
dc.subjectHEMATOPOIETIC STEM-CELLSen_US
dc.subjectPROGRESSIONen_US
dc.subjectLINEAGEen_US
dc.subjectIDENTITYen_US
dc.subjectMICEen_US
dc.subjectREVEALSen_US
dc.titleIdentification of renin progenitors in the mouse bone marrow that give rise to B-cell leukaemiaen_US
dc.typeArticleen_US
refterms.dateFOA2021-08-04T03:28:26Z


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