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dc.contributor.authorSadraei, Seyed Iraj
dc.date.accessioned2014-09-10T15:48:03Z
dc.date.available2014-09-10T15:48:03Z
dc.date.issued2014-09-10
dc.identifier.urihttp://hdl.handle.net/10464/5696
dc.description.abstractThis thesis describes a method involving the preparation of an L-proline-derived imidazolone protected with an N-triethylsilyl group that undergoes diastereoselective lithiation followed by electrophile quench to give C5-substituted products with syn stereochemistry. The N-silylated derivatives may be more easily N-deprotected as compared to previous N-t-Bu analogues to give secondary ureas. These may serve as precursors to N-phenyl chiral bicyclic guanidines or as NHC precursors for synthesis of corresponding complexes.en_US
dc.language.isoengen_US
dc.publisherBrock Universityen_US
dc.subjectL-proline-deriveden_US
dc.subjectimidazolone protecteden_US
dc.subjectdiastereoselective lithiationen_US
dc.subjectchiral guanidinesen_US
dc.subjectN-heterocyclic carbene complexesen_US
dc.titleDiastereoselective Lithiation-Substitution of N-Silyl-Protected-(S)-Tetrahydro-1H-pyrrolo[1,2-c]imidazole-3(2H)-ones and Applications of Their Derivativesen_US
dc.typeElectronic Thesis or Dissertationen_US
dc.degree.nameM.Sc. Chemistryen_US
dc.degree.levelMastersen_US
dc.contributor.departmentDepartment of Chemistryen_US
dc.degree.disciplineFaculty of Mathematics and Scienceen_US
dc.embargo.termsNoneen_US


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