The Role of Orexin-A in Anxiety and the Emission of Ultrasonic Vocalizations in Rats
dc.contributor.author | Morden, Alexandra K | |
dc.date.accessioned | 2013-10-11T20:08:12Z | |
dc.date.available | 2013-10-11T20:08:12Z | |
dc.date.issued | 2013-10-11 | |
dc.identifier.uri | http://hdl.handle.net/10464/5064 | |
dc.description.abstract | Central administration of orexin-A has been shown to activate autonomic arousal in rats, reliably inducing anxiety-like behaviours in the open field. To date, there has yet to be a study investigating the role of orexin-A in the communication of such negative affective state. In the current study, forty-six adult male rats were chronically cannulated and administered orexin-A into the medial preoptic area/anterior hypothalamic area to determine the effect of this neuropeptide on anxiety-like behaviour and the production of 22 kHz aversive ultrasonic vocalizations. It was found that intracerebral administration of orexin-A increased autonomic arousal as measured by a significant increase in fecal boli output, however orexin-A did not significantly affect locomotor activity or induce 22 kHz calling. These data suggest that orexin-A is involved in the regulation of the autonomic aspect of anxiety-like behaviour but not in the vocal communication of such negative affect | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Brock University | en_US |
dc.subject | Orexin-A; Anxiety-like behaviour; 22 kHz calls; Ultrasonic vocalizations; Rat | en_US |
dc.title | The Role of Orexin-A in Anxiety and the Emission of Ultrasonic Vocalizations in Rats | en_US |
dc.type | Electronic Thesis or Dissertation | en |
dc.degree.name | M.A. Psychology | en_US |
dc.degree.level | Masters | en_US |
dc.contributor.department | Department of Psychology | en_US |
dc.degree.discipline | Faculty of Social Sciences | en_US |
dc.embargo.terms | None | en_US |
refterms.dateFOA | 2021-08-03T02:16:11Z |