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Investigation of the Expression of Glucose Transporter Proteins in Human Cancer Cells

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dc.contributor.author Barron, Carly
dc.date.accessioned 2012-08-15T12:24:25Z
dc.date.available 2012-08-15T12:24:25Z
dc.date.issued 2012-08-15
dc.identifier.uri http://hdl.handle.net/10464/4087
dc.description.abstract Cancer cells are known to display increased glucose uptake and consumption. The glucose transporter (GLUT) proteins facilitate glucose uptake, however, their exact role in cancer metabolism remains unclear. The present study examined mRNA and protein expression of GLUT1, GLUT3, GLUT4 and GLUT12 in lung, breast and prostate cancer cells and corresponding noncancerous cells. Additionally, GLUT expression was determined in tumours from mice xenografted with human cancer cells. Differences in the mRNA and protein expression of GLUTs were found between cancerous and corresponding noncancerous cells. These findings demonstrate abundant expression of GLUT1 in cancer and highlight the importance of GLUT3 as it was expressed in several cancer cells and tumours. GLUT expression patterns in vitro were supported by the in vivo findings. The study of GLUT protein expression in cancer is important for understanding cancer metabolism and may lead to identification of biomarkers of cancer progression and development of target therapies. en_US
dc.language.iso eng en_US
dc.publisher Brock University en_US
dc.subject epithelial cancer, GLUT1, GLUT3, GLUT4, GLUT12 en_US
dc.title Investigation of the Expression of Glucose Transporter Proteins in Human Cancer Cells en_US
dc.type Electronic Thesis or Dissertation en_US
dc.degree.name M.Sc. Applied Health Sciences en_US
dc.degree.level Masters en_US
dc.contributor.department Applied Health Sciences Program en_US
dc.degree.discipline Faculty of Applied Health Sciences en_US


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