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Enantiodivergent chemoenzymatic synthesis of Balanol and approaches to the synthesis of (+)-Codine
(Brock University, 2010-10-25)
The present thesis reviews the development of a formal enantiodivergent synthesis of the (+)- and (-)-isomers of balanol. This approach commences from a cis-dihydrodiol derived from the enzymatic ...
Development of thermally stable versions of the Burgess Reagent : approaches to the chemoenzymatic total synthesis of morphine
(Brock University, 2011-10-14)
The present studies describe our recent work on expanding the use of the Burgess reagent and its reaction with oxiranes. Several new variants of the Burgess reagent and its chiral auxiliary version were evaluated for ...