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dc.contributor.authorHerbst, Eric
dc.date.accessioned2011-09-09T16:07:53Z
dc.date.available2011-09-09T16:07:53Z
dc.date.issued2011-09-09
dc.identifier.urihttp://hdl.handle.net/10464/3397
dc.description.abstractThe pyruvate dehydrogenase (PDH) complex regulates the oxidation of carbohydrates in mammals. Decreased activation of PDH following exhaustive exercise may aid the resynthesis of glycogen through increased activity of PDH kinase-4 (PDK4), one of four kinases that decrease the activity of the PDH complex. The purpose of this study was to examine the role of PDK4 in post-exercise glycogen resynthesis. Wild-type (WT) and PDK4-knockout (PDK4-KO mice) were exercised to exhaustion and were sampled at rest (Rest), at exercise exhaustion (Exh), and after two-hours post-exercise (Rec). Differences in feeding post-exercise led to the addition of a PDK4-KO group, pair-fed (PF) with WT mice. Glycogen fully recovered in all Rec groups in muscle however remained low in the PF group in liver. Flux through PDH was elevated in PDK4-KO muscle with feeding and low in the PF group in both tissues. This suggests PDK4 may fine-tune flux through PDH during exercise recovery.en_US
dc.language.isoengen_US
dc.publisherBrock Universityen_US
dc.subjectpyruvate dehydrogenaseen_US
dc.subjectglycogenen_US
dc.subjectexercise recoveryen_US
dc.subjectPDK4en_US
dc.titleThe Role of Pyruvate Dehydrogenase Kinase-4 in Post-Exercise Glycogen Recoveryen_US
dc.typeElectronic Thesis or Dissertationen_US
dc.degree.nameM.Sc. Applied Health Sciencesen_US
dc.degree.levelMastersen_US
dc.contributor.departmentApplied Health Sciences Programen_US
dc.degree.disciplineFaculty of Applied Health Sciencesen_US


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