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dc.contributor.authorGilmet, Jacqueline
dc.date.accessioned2010-10-25T19:33:51Z
dc.date.available2010-10-25T19:33:51Z
dc.date.issued2010-10-25
dc.identifier.urihttp://hdl.handle.net/10464/3033
dc.description.abstractThe present thesis reviews the development of a formal enantiodivergent synthesis of the (+)- and (-)-isomers of balanol. This approach commences from a cis-dihydrodiol derived from the enzymatic dihydroxylation of bromobenzene. The stereochemistry of the diol is used to direct the synthesis of two different aziridines, each used in the formal synthesis of one enantiomer of balanol. Also described are several enantioselective approaches to (+ )-codeine. Each strategy begins with the enzymatic dihydroxylation of p-bromoethylbenzene and involves a Mitsunobu inversion and intramolecular Heck reaction as key steps.en_US
dc.language.isoengen_US
dc.publisherBrock Universityen_US
dc.subjectOrganic compounds -- Synthesisen_US
dc.subjectCodeine -- Synthesisen_US
dc.titleEnantiodivergent chemoenzymatic synthesis of Balanol and approaches to the synthesis of (+)-Codineen_US
dc.typeElectronic Thesis or Dissertationen_US
dc.degree.nameM.Sc. Chemistryen_US
dc.degree.levelMastersen_US
dc.contributor.departmentDepartment of Chemistryen_US
dc.degree.disciplineFaculty of Mathematics and Scienceen_US


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