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Enantiodivergent chemoenzymatic synthesis of Balanol and approaches to the synthesis of (+)-Codine
(Brock University, 2010-10-25)
The present thesis reviews the development of a formal enantiodivergent
synthesis of the (+)- and (-)-isomers of balanol. This approach commences from a
cis-dihydrodiol derived from the enzymatic ...
How Learning Styles, Chemistry Attitudes and Experiences, Confidence, and Demographics Correlate with Academic Success in First and Second Year Chemistry Courses
(2013-04-08)
At Brock University, the Faculty of Mathematics and Science currently has one of the
highest percentages of students on academic probation, with many students reporting the
most difficulty with Introductory Chemistry in ...
New Building Blocks for Dual-Property Molecule-Based Magnets
(2013-04-15)
Two classes of compounds have been prepared and characterized as building blocks for chiral magnets and ferromagnetic conductors. In the fIrst project, the organic framework of a pentadentate, (N302) macro cycle has been ...
Molecular Magnetism: The Design, Synthesis, and Characterization of New Building Blocks for Molecule-based Magnetic Materials
(2013-04-08)
Two classes of building blocks have been prepared and characterized and their
coordination chemistry explored working towards the preparation of new molecule-based
magnetic materials. In the first project, the amine ...
The Synthesis of Imidazole Fatty Acid Conjugates as Inhibitors of Apoptosis
(Brock University, 2013-03-14)
Ionizing radiation is known to initiate apoptosis in mammalian cells by causing the transformation of cytochrome c into a peroxidase, which results in the specific peroxidation of the mitochondrial phospholipid cardiolipin. ...
Application of thermal ion-molecule reactions in tackling spectroscopic inferences in inductively coupled plasma mass spectrometry
(2013-04-19)
Part I: Ultra-trace determination of vanadium in lake sediments: a performance comparison using O2, N20, and NH3 as reaction gases in ICP-DRC-MS
Thermal ion-molecule reactions, targeting removal of specific spectroscopic ...
Experimental and Computational Studies on Copper and Hydrobenzoin Derivatives in Catalytic Asymmetric Reactions
(2013-05-07)
The use of theory to understand and facilitate catalytic enantioselective
organic transformations involving copper and hydrobenzoin derivatives
is reported. Section A details the use of theory to predict, facilitate, ...
Understanding the Origin of Selectivity in the Asymmetric Lithiation Reaction of N-Heterocycles: A Theoretical Study
(Brock University, 2012-11-07)
The natural abundance of the N-heterocycle containing compounds has pushed the synthetic community toward the invention of new synthetic methods that result in the structural diversity of N-heterocycles. Among this, is the ...
Model studies toward the total synthesis of thebaine by an intramolecular cycloaddition strategy
(Brock University, 2014-01-27)
The present studies describe recent progress toward the synthesis of the thebaine. Model substrates were synthesized using pyridazine derivatives as a starting material, which allowed to assess the key Diels-Alder reaction ...
Asymmetric hydrogenation of alkenes with cationic iridium(I) complexes of 2-phosphino-1-aminoferrocene ligands
(Brock University, 2011-03-08)
Iridium complexes with bidentate P,N ligands represent a class of catalysts that
significantly expand the application range of asymmetric hydrogenation. New substrate
classes, for which there have ...