Abstract:
This research work has been planned with
the intention of proving the absolute configuration
of lactobacillc acid. During the course of this work,
attempts have been made to synthesize cis-2-carboxycyclopropane-
l-.acetic acid as,v,a suitable resolvable
material. As the results were not satisfactory, the
synthesis of ci,s-2-carboxycyclopropane-l-propionic acid
has been alternatively attempted by ring opening of
bicyclo- [4.1.~-heptan-2-onewithout much success.
Attempts to resolve or prepare bicyclo[
4.1.~-hePtan-2-one optically active are also reported.
On the other hand, a complete scheme is
described for the possible synthesis of optically
active lactobacillic acid.
If only bicyclo- ~.1.~ -heptan-2-one can
be resolved or prepared optically active, this described
scheme can be applied smoothly to the synthesis
of enant~omeric lactobacillic acid.
