Abstract:
This research work has been planned with the intention of
synthesizing optically active bicyclo[3,l,0]-hexan-2-one using chiral
carbodiimides.
Several carbodiimides have been prepared for practice and for
attempts at asymmetric induction. The total synthesis of dibenzo[e,g]-
(l:3)diazonine and the partial synthesis of l:13-dimethyldibenzo[e,g]-
(l:3)diazonine are reported.
Attempts to resolve 6,6f-dimethyl-2,2t-diphenic acid were not
successful. The NMR spectra of carbodiimides and the related thioureas
are compared.
The reaction transition state of the 4-hydroxycyclohexanone with
optically pure R,R(+)-di(a-phenylethyl)-carbodiimide has been considered.
The ORD application to chiral cyclohexanones is discussed.
