Abstract:
A strain of Drosophila melanogaster (mid america
stock culture no. hl16) has been reported to be deficient
in aldehyde oxidase activity (Hickey and Singh 1982).
This strain was characterized during the course of this
study and compared to other mutant strains known to be
deficient in aldehyde oxidase activity. During the course
of this investigation, the hl16 strain was found to be
temperature sensitive in its viability. It was found that
the two phenotypes, the enzyme deficiency, and the temperature
sensitive lethality were the result of two different
mutations, both mapping to the X-chromosome. These two
mutations were found to be separable by recombination. The
enzyme deficiency was found to map to the same locus as the
cinnamon mutation, another mutation which affects aldehyde
oxidase production. The developmental profile of aldehyde
oxidase in the hl16 strain was compared to the developmental
profile in the Canton S wild type strain. The aldehyde oxidase
activity in adult hl16 individuals was also compared
to that of various other strains. It was also found that
the aldehyde oxidase activity was temperature sensitive in
the adult flies.
The temperature sensitive lethality mutation was mapped
to position 1-0.1.
