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dc.contributor.authorStaples, Elizabeth M.en_US
dc.date.accessioned2009-06-04T14:09:18Z
dc.date.available2009-06-04T14:09:18Z
dc.date.issued2006-06-04T14:09:18Z
dc.identifier.urihttp://hdl.handle.net/10464/1530
dc.description.abstractThis thesis investigated whole body glucose disposal and the adaptive changes in skeletal muscle carbohydrate metabolism following 28 d of supplementation with 1000 mg R(+)-lipoic acid in young sedentary males (age, 22.1 ± 0.67 yr, body mass, 78.7 ± 10.3 kg, n=9). In certain individuals, lipoic acid decreased the 180-min area under the glucose concentration and insulin concentration curve during an oral glucose tolerance test (OGTT) (n=4). In the same individuals, lipoic acid supplementation decreased pyruvate dehydrogenase kinase activity (PDK) (0.09 ± 0.024 min"^ vs. 0.137 ± 0.023 min'\ n=4). The fasting levels of the activated form of pyruvate dehydrogenase (PDHa) were decreased following lipoic acid (0.42 ± 0.13 mmol-min'kg'^ vs. 0.82 ± 0.32 mmolrnin'^kg"\ n=4), yet increased to a greater extent during the OGTT (1.21 ± 0.34 mmol-min'kg"' vs. 0.81 ±0.13 mmolmin"'kg'\ n=4) following hpoic acid supplementation. No changes were demonstrated in the remaining subjects (n=5). It was concluded that improved glucose clearance during an OGTT following lipoic acid supplementation is assisted by increased muscle glucose oxidation through increased PDHa activation and decreased PDK activity in certain individuals.en_US
dc.language.isoengen_US
dc.publisherBrock Universityen_US
dc.subjectGlucoseen_US
dc.subjectMusclesen_US
dc.subjectThioctic acid.en_US
dc.subjectPyruvate kinase.en_US
dc.subjectMusculoskeletal system.en_US
dc.titleThe effects of R(+)-lipoic acid supplementation on regulation of human skeletal muscle pyruvate dehydrogenaseen_US
dc.typeElectronic Thesis or Dissertationen_US
dc.degree.nameM.Sc. Applied Health Sciencesen_US
dc.degree.levelMastersen_US
dc.contributor.departmentApplied Health Sciences Programen_US


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