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The effects of R(+)-lipoic acid supplementation on regulation of human skeletal muscle pyruvate dehydrogenase

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dc.contributor.author Staples, Elizabeth M. en_US
dc.date.accessioned 2009-06-04T14:09:18Z
dc.date.available 2009-06-04T14:09:18Z
dc.date.issued 2006-06-04T14:09:18Z
dc.identifier.uri http://hdl.handle.net/10464/1530
dc.description.abstract This thesis investigated whole body glucose disposal and the adaptive changes in skeletal muscle carbohydrate metabolism following 28 d of supplementation with 1000 mg R(+)-lipoic acid in young sedentary males (age, 22.1 ± 0.67 yr, body mass, 78.7 ± 10.3 kg, n=9). In certain individuals, lipoic acid decreased the 180-min area under the glucose concentration and insulin concentration curve during an oral glucose tolerance test (OGTT) (n=4). In the same individuals, lipoic acid supplementation decreased pyruvate dehydrogenase kinase activity (PDK) (0.09 ± 0.024 min"^ vs. 0.137 ± 0.023 min'\ n=4). The fasting levels of the activated form of pyruvate dehydrogenase (PDHa) were decreased following lipoic acid (0.42 ± 0.13 mmol-min'kg'^ vs. 0.82 ± 0.32 mmolrnin'^kg"\ n=4), yet increased to a greater extent during the OGTT (1.21 ± 0.34 mmol-min'kg"' vs. 0.81 ±0.13 mmolmin"'kg'\ n=4) following hpoic acid supplementation. No changes were demonstrated in the remaining subjects (n=5). It was concluded that improved glucose clearance during an OGTT following lipoic acid supplementation is assisted by increased muscle glucose oxidation through increased PDHa activation and decreased PDK activity in certain individuals. en_US
dc.language.iso eng en_US
dc.publisher Brock University en_US
dc.subject Glucose en_US
dc.subject Muscles en_US
dc.subject Thioctic acid. en_US
dc.subject Pyruvate kinase. en_US
dc.subject Musculoskeletal system. en_US
dc.title The effects of R(+)-lipoic acid supplementation on regulation of human skeletal muscle pyruvate dehydrogenase en_US
dc.type Electronic Thesis or Dissertation en_US
dc.degree.name M.Sc. Applied Health Sciences en_US
dc.degree.level Masters en_US
dc.contributor.department Applied Health Sciences Program en_US


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