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dc.contributor.authorBorra, Suresh
dc.contributor.authorKumar, Manoj
dc.contributor.authorMcNulty, James
dc.contributor.authorBaidilov, Daler
dc.contributor.authorHudlicky, Tomas
dc.date.accessioned2019-01-16T18:39:13Z
dc.date.available2019-01-16T18:39:13Z
dc.date.issued2018-10-19
dc.identifier.citationEur. J. Org. Chem. 2019, 77–79en_US
dc.identifier.issn1099-0690
dc.identifier.urihttp://hdl.handle.net/10464/13884
dc.description.abstractA total synthesis of the fungal-derived natural prod-uct pestynol is reported via a convergent chemoenzymatic ap-proach from the readily available precursors geranyl bromide,ethyl acetoacetate, trimethylsilylacetylene, and bromobenzene. Synthetic (–)-pestynol proved to be identical in all respects to thenatural material, allowing confirmation of the structure includ-ing absolute stereochemistry.en_US
dc.description.sponsorshipNatural Sciences and Engineering Research Council of Canada (NSERC), Canada Foundation for Innovation (CFI), Canada Research Chair Program, TDC Research Foundation and The Advanced Bio-manufacturing Centre at Brock University.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjecttotal synthesisen_US
dc.subjectNatural product synthesisen_US
dc.subjectSonogashira couplingen_US
dc.subjectYne-dieneen_US
dc.subjectchemoenzymatic dihydroxylationen_US
dc.titleChemoenzymatic Synthesis of the Antifungal Compound(–)-Pestynol by a Convergent, Sonogashira Construction of the Central Yne-Dieneen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/ejoc.201801470


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