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dc.contributor.authorBaidilov, Daler
dc.contributor.authorRycek, Lukas
dc.contributor.authorTrant, John F.
dc.contributor.authorFroese, Jordan
dc.contributor.authorMurphy, Brennan
dc.contributor.authorHudlicky, Tomas
dc.date.accessioned2019-01-03T14:29:27Z
dc.date.available2019-01-03T14:29:27Z
dc.date.issued2018-05-11
dc.identifier.citationAngew. Chem. Int. Ed. 2018, 57, 10994–10998.en_US
dc.identifier.issn1521-3773
dc.identifier.urihttp://hdl.handle.net/10464/13871
dc.description.abstractThe advanced intermediates in the syntheses of tetrodotoxin reported by Fukuyama, Alonso, and Sato were prepared. The key steps in the synthesis of the title compounds involved the toluene dioxygenase–mediated dihydroxylation of either iodobenzene or benzyl acetate. The resulting diene diols were transformed to Fukuyama’s intermediate in six steps, to Alonso’s intermediate in nine steps and to Sato’s intermediate in ten steps, respectively.en_US
dc.description.sponsorshipNSERC Idea to Innovation - I2IPJ-470630-14 NSERC Discovery Grant - RGPIN-2018-03723en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjecttetrodotoxinen_US
dc.subjectNatural product synthesisen_US
dc.subjectchemoenzymatic dihydroxylationen_US
dc.titleChemoenzymatic Approach to Tetrodotoxin: Synthesis of Fukuyama’s, Alonso’s, and Sato’s Advanced Intermediatesen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/anie.201804602


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